| abstract |
(57) Abstract: A novel oligonucleotide analogue having stable and excellent antisense or antigene activity, or excellent activity as a detection agent (probe) for a specific gene or a primer for initiating amplification is provided. An object of the present invention is to provide a nucleic acid reagent and a drug containing the same, and a nucleic acid reagent containing a novel nucleoside analog which is an intermediate for producing the same. SOLUTION: General formula (1) [Wherein, R 1 and R 2 are the same or different and are each a hydrogen atom, A represents a phosphoric acid group or the like, A represents an alkylene group having 1 to 4 carbon atoms, B represents a purin-9-yl group, 2-oxo- A 1,2-dihydropyrimidin-1-yl group or a substituted purin-9-yl group or a substituted 2-oxo-1,2-dihydropyrimidin-1-yl group is shown. ] The nucleic acid reagent containing the compound represented by these, or its salt. |