| abstract |
PROBLEM TO BE SOLVED: To obtain a granule obtained by adding and mixing a lubricant and granulating the granulated product by a dry granulation method (dry crushing method, melt granulation method). It is an object of the present invention to provide a tablet which does not cause disintegration delay after administration to a living body or in a solution. SOLUTION: The following components (a) to (d): (a) sucrose fatty acid ester, (b) hydrogenated oil, (c) polyethylene glycol, (d) a bioactive drug, A tablet comprising: The tablet having the above-described structure can significantly reduce the disintegration time delay of the tablet caused by the effect of heat storage after long-term storage, storage under high-temperature, high-humidity conditions, or film coating. is there. |