| abstract |
(57) [Summary] (Modified) [Problem] To provide an inflammatory factor activation inhibitor which suppresses the expression of an inflammatory protein and the activation of a gene transcription regulatory factor related thereto, and a use thereof. A cystine derivative of the general formula I and an inflammatory factor activation inhibitor containing the cystine derivative as an active ingredient. [N and m are integers of 0 to 5, Ar 1 and Ar 2 are a 2-hydroxyaryl group or a heterocyclic group, and the 2-hydroxyaryl group and the heterocyclic group are substituted with a halogen atom, a hydroxyl group, a cyano group, or the like. C1-C4 alkyl group, Alkoxy group C1 -C6, hydroxyalkyl group C1 -C6, etc., R 1 and R 4 are H, alkyl group and phenyl group, a C1 -C6. X and Y are O or NH. R 2 and R 3 are H, an alkyl group of C1 to C20, C7 to C16 Aralkyl groups and the like. T and V are H, a C1-C6 alkyl group. ] |