| abstract |
PROBLEM TO BE SOLVED: To provide a Frizzled-6 polypeptide and polynucleotide and a method for producing the polypeptide by a recombinant method. SOLUTION: The nucleotide sequence encoding a polypeptide which is at least 80% identical in its entire length to the nucleotide sequence encoding the Frizzled-6 polypeptide of SEQ ID NO: 2 and which has the activity of the Frizzled-6 polypeptide, or this nucleotide sequence A polynucleotide comprising a nucleotide sequence complementary to is isolated. [Effect] Frizzled-6 polypeptide and polynucleotide are used for infectious diseases, pain, cancer, diabetes, obesity, anorexia, Overeating, asthma, Parkinson's disease, acute heart failure, hypotension, hypertension, urination, osteoporosis, angina, myocardial infarction, ulcer, It is useful in treating dysfunctions or diseases, including allergies, benign prostatic hyperplasia, and psychiatric and neurological disorders, and diagnostic assays for such conditions. |