| abstract |
PROBLEM TO BE SOLVED: To obtain a novel protein having a drug efflux transporter activity, a DNA encoding the protein, a method for screening a compound which promotes or inhibits the activity of the protein, and a method for screening the same. Provision of compounds, etc. A protein having an amino acid sequence identical or substantially identical to a specific amino acid sequence derived from human. The protein is useful as a diagnostic marker for drug resistance such as an anticancer drug, and compounds that promote or inhibit the activity of the protein obtained by a screening method using the protein include, for example, cancer, infectious disease, asthma, It can be used as a prophylactic / therapeutic agent for diseases such as inflammatory diseases. |