| abstract |
(57) [Summary] (Modifications) [Problem] To prevent and / or treat heart failure by a compound that is an endothelin antagonist. SOLUTION: As the compound represented by the formula (I), for example, (+)-(5RS, 6SR, 7SR) -2-butyl-6 An endothelin antagonist of -carboxy-7- (2-carboxypropyl-4-methoxyphenyl) -5- (3,4-methylenedioxyphenyl) cyclopenteno [1,2-b] pyridine or a pharmaceutically acceptable one thereof A preventive and / or therapeutic agent for heart failure and ventricular dysfunction in a warm-blooded animal, comprising a salt. (In the formula, Ar 1, Ar 2 represents a hydrogen atom on independently aromatic ring is replaced by a halogen atom, hydroxyl group, R 1 to R 3 represents a hydrogen atom, a hydroxyl group or an alkyl group, and Y represents -CO- R 4 , SO 3 H, etc., wherein A has a double bond, and a 5- or 6-membered heteroaromatic ring containing any one to four heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur. Indicates) |