| abstract |
(57) [Summary] [PROBLEMS] To suppress the by-product of a symmetric urea compound and obtain a good yield. Provided is a simple method for producing an asymmetric urea compound, which is more versatile than conventional methods and can be used on an industrial scale. SOLUTION: Step 1: adding a pyridine base and one of an aromatic amine represented by Formula 1: ArNH 2 and an amine represented by Formula 2: NHR 1 R 2 to a solvent, Step 2: adding phenyl chlorocarbonate And a step of reacting by adding and reacting the aromatic amine of the formula 1 with the amine of the formula 2 which has not been added in the step 1. Formula 3: ArNHCONR 1 R 2 asymmetry method for producing urea compounds; however, C1 to which R 1 may have a substituent 12 alkyl groups or C7-12 aralkyl groups, And R 2 is H, and R 1 and R 2 are adjacent N When forming a ring with, an aromatic amine of formula 1 is added in step 1 and an amine of formula 2 is added in step 3. (Each symbol in the formula is synonymous with the description.) |