| abstract |
PROBLEM TO BE SOLVED: To prevent endothelial dysfunction and decrease in availability of NO by blood vessels, to prevent the onset, enlargement and complication of atherosclerotic lesions, Provided are compounds that are effective in preventing bypass, vasodilation, revascularization and vascular complications after heart transplantation, or in treating myocardial or peripheral ischemia, heart failure and pulmonary arterial hypertension. SOLUTION: Formula (I): [Wherein X is a 5- to 12-membered heterocyclic ring or the like; n is 0 or 1; R 1 is a hydrogen atom or the like; Ra is a single bond or the like; A nitrogen atom or the like; E is a nitrogen atom or the like; Rb is a single bond or the like; W represents an aryl or the like], optical isomers, hydrates, solvates, and pharmaceutically acceptable salts thereof. Its addition salts with acids. |