| abstract |
(57) [Summary] (Modified) [Solution] General formula (I) [Wherein, ring A and ring B each represent an aromatic ring, -X- represents -NR 0- , -S- or -O-; 0 represents a hydrogen atom or a lower alkyl group, and -Y is (1) -NR 1 R 2 (wherein, R 1 is a lower alkyl group, a lower alkenyl group, or a lower alkynyl group, and R 2 is Represents an organic group other than a lower alkyl group. Or R 1 and R 2 together with a nitrogen atom may form a saturated or unsaturated 5- to 7-membered heterocyclic ring which may be substituted by a halogen atom, a hydroxyl group or an oxo group. ), (2) -C (= O) -NR, (3) -C (OH) R, or (4) an optionally substituted saturated or unsaturated 5- to 7-membered heterocyclic group] or a pharmaceutically acceptable derivative thereof. Salt. [Effect] The compound of the general formula (I) has an ability to suppress osteoclast differentiation induction, and is useful as an anti-inflammatory agent, an anti-rheumatic drug or a therapeutic agent for a disease associated with bone regeneration deficiency. |