abstract |
(57) [Summary] The present invention relates to a biocompatible anionic polymer comprising fibrosis, The present invention relates to the finding that scar formation and surgical adhesions can be effectively suppressed. The present invention provides the finding that anionic polymers effectively inhibit cell invasion associated with undesirable healing processes, and in particular that the effectiveness of anionic polymers to inhibit cell invasion is related to the negative charge density of the polymer. Based on knowledge. The present invention provides a method for inhibiting fibrosis in a mammal, comprising combining an effective amount of pentosan polysulfate with a pharmaceutically acceptable gel, graft or polymer carrier to inhibit fibrosis. And a method for producing the drug. |