| abstract |
(57) [Summary] (Modified) [Problem] To provide an external antiphlogistic analgesic which enhances the skin permeability of a nonsteroidal antiphlogistic analgesic as a main agent and exhibits excellent pharmacological effects. SOLUTION: Non-steroidal anti-inflammatory analgesic agent 0.1 to 5.0 An external anti-inflammatory and analgesic composition comprising wt% and 0.02 to 10.0 wt% of an antihistamine. Non-steroidal anti-inflammatory analgesics include flurbiprofen, ketoprofen, Examples include ibuprofen, indomethacin, piroxicam, diclofenac sodium or loxoprofen sodium. Examples of the antihistamine include diphenylpyramine hydrochloride, diphenhydramine hydrochloride, clemastine fumarate, chlorpheniramine maleate, mequitazine and the like. |