abstract |
(57) Abstract: inducing an immune response against β2 glycoprotein I (beta 2 GPI) reactive T cells to induce the production of anti-phospholipid antibody which is a causative agent of antiphospholipid antibody syndrome (APS) Provided are a peptide and an agent for treating or preventing APS containing the peptide as an active ingredient. A peripheral blood were stimulated with β 2 GPI, β 2 GPI Reactive T cell lines are established, and their TCR portions are subjected to gene analysis. beta 2 to the TCRβ chain of GPI-reactive T cells are Vβ7 and Vβ8 is used frequently, beta 2 G The presence of a specific amino acid motif in the CDR3 of the TCRβ chain of PI-reactive T cells, and the existence of a TCRβ having the same amino acid sequence in the CDR3 region from multiple APS patients Due to the presence of the chain, a peptide containing the amino acid sequence of this CDR3 region is used to elicit an immune response against β 2 GPI-responsive T cells. |