| abstract |
(57) [Summary]n[PROBLEMS] Mostly type 5 cyclic guanosine 3 ', 5'-monophosphate phosphodiesterase (cGMP PD E5) is an inhibitor of various therapeutic fields (male erectile function) Series of pyrazolo [4,3-d] useful in A pyrimidin-7-one compound is provided.nSOLUTION: Formula (I):nEmbedded imagen Or a pharmaceutically or veterinarily acceptable compound thereof Functional salts, prodrugs, polymorphs and / or solvates A process for producing a compound of formula (II), (II) I), (IV) or (V):nEmbedded imagen Embedded imagen (Each compound is defined in claim 1 of this specification) Is -OR) Three And in the presence of hydroxide scavengers Or a compound of the formula (IV) or (V) In the case of the compound of the above, the auxiliary base and the hydroxide scavenger That is, -OR Three Is substituted with the auxiliary base) It is a method including reacting in the presence. |