| abstract |
(57) Abstract: A matrix metalloprotease inhibitor containing a novel sulfonamide derivative having succinimide. SOLUTION: General formula (I): Wherein R 1 is a hydrogen atom, C1-C6 alkyl, etc., R 2 is a hydrogen atom, C1-C6 alkyl, aryl, etc., R 3 is a single bond, arylene or heteroarylene; R 4 is a single bond, -CH = CH-, -C≡C-, CO-NH-, -NH- R 5 represents an optionally substituted aryl, such as CO— and —O—. ], A compound thereof, an optically active form thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof, Or their solvates. |