abstract |
(57) [Summary] (Modifications) [Problem] To provide proteins involved in cell cycle regulation and polynucleotides thereof. Kind Code: A1 A cell cycle regulatory protein that regulates the binding specificity of the SCF complex to p27, a polynucleotide encoding the protein, an oligonucleotide that hybridizes with the polynucleotide under stringent conditions, and a binding to the protein. Antibodies or fragments thereof, A screening method for a substance having an activity of inhibiting the binding of the protein to p27 and inhibiting cell cycle progression, containing the polynucleotide, the antibody or a fragment thereof, or a substance obtained by the screening method. Pharmaceutical composition. |