abstract |
(57) Abstract: An object of the present invention is to provide an anaerobic bacterium belonging to the genus Bifidobacterium, which is effective for gene therapy of solid tumors and safer as a gene transfer carrier by human accumulation, and An object of the present invention is to provide a medicine characterized by containing the above anaerobic bacteria. SOLUTION: A DNA encoding a protein having an antitumor activity or a DNA encoding a protein having an activity of converting a precursor of an antitumor substance into an antitumor substance is specifically transported to a tumor tissue under an anaerobic environment, A microorganism belonging to the genus Bifidobacterium capable of expressing a protein encoded by the DNA, and a medicament containing the same. |