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publicationDate 2002-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2002095382-A
titleOfInvention Preparation of animal model for primary liver cancer
abstract (57) [Problem] To provide a method for simply and reliably producing a primary liver cancer model animal. SOLUTION: An F344 (Fischer) rat is treated with diethylnitrosamine (DEN) 20 mg / day. A single dose of ≥kg body weight and choline-deficient amino acids (CD AA) A method for producing a primary liver cancer model animal by breeding a diet for at least 64 weeks and then a normal diet for at least 8 weeks, and a primary liver cancer model animal produced by the method.
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