| abstract |
PROBLEM TO BE SOLVED: To provide a method for treating a cyclooxygenase (COX-2) mediated disease to be administered to a patient in need of treatment for an inflammatory disease sensitive to treatment with a nonsteroidal anti-inflammatory drug. A novel compound of the following formula (I) or a pharmaceutically acceptable salt thereof. Further, a method of treating a COX-2 mediated disease comprising administering to a patient in need thereof a non-toxic therapeutically effective amount of a compound of the formula (I) and a compound of the formula (I) for treating a COX-2 mediated disease. Some pharmaceutical compositions comprising the compounds are included. [Wherein, R 1 is CH 3 , NH 2 , NHC (O) CF 3 And NHCH 3 , wherein Ar Is mono -, di- - or tri - substituted phenyl, where the substituents are selected from hydrogen, C 1-6 alkoxy, C 1-6 alkylthio, CN, from the group consisting of C 1-6 alkyl, etc., R 2 is halo, C 1-6 alkoxy, C 1-6 alkylthio, C 1-6 alkyl is selected from the group consisting of N 3, etc.] |