| abstract |
(57) [Summary] [Problem] To provide a composition for alleviating pathological symptoms associated with enhanced phospholipase A (2) activity and treating or preventing related diseases. The present invention provides a compound represented by the general formula (1): (In the formula, X, Y and Z represent an oxygen atom or a sulfur atom, R 1 represents a hydrogen atom or the like, R 2 represents an optionally substituted phenyl group, an optionally substituted naphthyl group or the like; Three Represents an optionally substituted alkyl group, an optionally substituted cycloalkyl group and the like, and R 4 represents a hydrogen atom, an alkyl group and the like. ) Or a pharmaceutically acceptable complex thereof as an active ingredient. The composition of the present invention reduces pathological symptoms associated with enhanced phospholipase A (2) activity, exhibits an extremely effective action for treating or preventing related diseases, and includes inflammatory diseases and / or allergic diseases. It is useful as a therapeutic agent for. |