| abstract |
PROBLEM TO BE SOLVED: To provide a DDS compound having excellent stability in serum and capable of site-selectively transferring a pharmaceutical compound as an active ingredient to a tumor site or the like. SOLUTION: The formula (I): AWN (R 1 ) -C (R 2 ) (R 3 ) -OQ (A Represents a macromolecule that is a drug carrier; W represents a spacer containing one amino acid residue bonded to the nitrogen atom at the C-terminus or a peptide-bonded 2 bonded to the nitrogen atom at the C-terminus A spacer containing an oligopeptide residue composed of 8 amino acid residues from R 1 , R 2 , and R 3 represents a hydrogen atom, an alkyl group, an aryl group, a carboxyl group, or an alkoxycarbonyl group; Any two of R 1 , R 2 , and R 3 may be bonded to each other to form a 4- to 8-membered ring; OQ represents a residue of a pharmaceutical compound having a hydroxyl group) DDS compounds. |