| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f0d968cc0aa0dd9203010316f3f64574 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-66 |
| filingDate |
2000-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62a623ef9bf808e716cf431e7211e85a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8bbd7ba950a03161bd151f7cb1255f3 |
| publicationDate |
2002-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2002058489-A |
| titleOfInvention |
Method of screening for insulin sensitizer in diabetes |
| abstract |
(57) [Problem] It is an object of the present invention to elucidate the antidiabetic action mechanism of TZD from the ground up as soon as possible and to establish a system as an index for screening of a novel antidiabetic drug. The present invention relates to a method for screening a ligand of a PGC2-PPARγ complex, comprising: 1) a fusion protein containing a DNA binding domain and PGC2; 2) PPARγ; and 3) a region recognized by the DNA binding domain. , A promoter, and a vector containing a reporter gene operably linked to the promoter, a test substance is added, and PGC2 is expressed using the expression of the reporter gene as an index. A method comprising detecting regulation of transcriptional activity of the PPARγ complex. The present invention also relates to a fusion protein that can be used in the above-mentioned screening method, and a gene encoding the fusion protein. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005291819-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005328748-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004015415-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4527428-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1548434-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004015103-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1548434-A1 |
| priorityDate |
2000-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |