| abstract |
(57) [Problem] To provide a TNF-α production inhibitor useful as a therapeutic agent for an autoimmune disease such as rheumatoid arthritis. A novel compound having a structure represented by the general formula [1] or a salt thereof has excellent TNF-α production inhibitory activity. Embedded image Wherein A is-(NR 4 )-,-(CR 5 R 6 )-or -O-, B is an alkylene or alkenylene group, 1 , R 2 , R 4 , R 5 and R 6 are a hydrogen atom, an alkyl group, R 3 represents an aryl group or an unsaturated heterocyclic ring; X represents an oxygen atom or a sulfur atom; ] |