| abstract |
(57) [Summary] 4- (3- (4-morpholinobutyrylamino) phenyl) -2H-phthalazine represented by the formula (I): 1-one methanesulfonate monohydrate. Embedded image Effect The compound of formula (I) inhibits poly (ADP-ribose) polymerase, and causes various ischemic diseases (brain, heart, gastrointestinal tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel diseases) , Multiple brain sclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorders, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. It is also useful as a sensitizer for antiretroviral agents (such as HIV) and anticancer therapy. |