| abstract |
PROBLEM TO BE SOLVED: To provide a method for producing 4-cyano-3-hydroxybutyric acid ester which is an intermediate in an improved method for synthesizing (5R) -1,1-dimethylethyl 6-cyano-5-oxo-hexanoate. Offer. SOLUTION: Formula V Wherein X is a leaving group and R is C 1 -C 1 A compound of formula IVR 1 -C in a solvent at 0 ° C. to the reflux temperature of the solvent. N IV (wherein R 1 is a tetraalkylammonium, silver, copper (I), copper (II), alkali metal or alkaline earth metal) compound of formula II (Wherein R is as defined above). |