http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001526905-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6811 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6811 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate | 1998-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001526905-A |
| titleOfInvention | Methods for selecting flanking sequences that provide relative binding affinity to a ligand binding site |
| abstract | (57) [Summary]nA method of ranking the relative reactivity of nucleotide sequences flanking a ligand binding site. The method includes, and is useful for, coordinating several populations of nucleic acid molecules, each containing a ligand binding site and a flanking sequence on either side of the binding site. . In one embodiment, a method for ranking the reactivity of a polynucleotide flanking sequence is disclosed, the method comprising: (a) providing a plurality of different nucleic acid molecules, each of the molecules comprising Having the same ligand binding site adjacent to at least one flanking sequence, and (b) determining the relative binding affinity of the ligand for the binding sites in at least two of said molecules. Exposing the molecule to a ligand selective for the binding site under conditions; and (c) ranking the relative binding affinities determined in step (b) to provide the polynucleotide flanking sequence. Ranking the relative reactivity of In another embodiment, the higher binding affinity of the ligand binding site in the molecule corresponds to the higher reactivity of the flanking sequence. |
| priorityDate | 1997-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.