| abstract |
(57) [Summary]nIn accordance with the present invention, a new class of substituted pyridine compounds, optionally containing ether, ester, amide, ketone or thioether substituents, has been discovered that enhance the release of ligands involved in neurotransmission. The compounds of the present invention can modulate the acetylcholine receptor. Therapeutic applications of compounds having activity at the acetylcholine receptor include Alzheimer's disease and other disorders including memory loss and / or dementia, cognitive impairment; disorders of extrapyramidal motor function such as Parkinson's disease; Mood and emotional disorders, including Lazlet's syndrome and delayed dyskinesia, depression, anxiety and psychosis, substance abuse, including withdrawal symptoms and replacement therapy; dysregulation and endocrine disorders of food intake, including bulimia and anorexia; Control of disease and pain; autonomic neuropathy, including gastrointestinal motility and dysfunction such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; chromophilic cell tumors, and hypertension and heart Diseases of the central nervous system, such as cardiovascular disorders, including arrhythmias, as well as co-medication uses in surgical applications. |