http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001525813-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 1998-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001525813-A |
| titleOfInvention | Substituted tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptor |
| abstract | (57) [Summary] Formula (I): [Wherein, R 1 represents a hydrogen or halogen atom, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C 1-4 alkyl, C 1-4 alkoxy, aryl C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkoxy C 1-4 alkyl, C 3-6 cycloalkyl C 1-4 alkoxy, C 1-4 alkanoyl, C 1-4 alkoxycarbonyl, C 1- 4 alkylsulfonyl, C 1-4 alkylsulfonyloxy, C 1-4 alkylsulfonyl C 1-4 alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl C 1-4 alkyl, C 1-4 alkylsulfonamide, C 1- 4 alkylamide, C 1-4 alkyl sulfonamido C 1-4 alkyl, C 1-4 alkylamido C 1-4 alkyl, aryl sulfonate Bromide, aryl carboxamido, aryl sulfonamido C 1-4 alkyl, aryl carboxamide C 1-4 alkyl, aroyl, aroyl C 1-4 alkyl or aryl C 1-4 alkanoyl group, a group R 3 OCO (CH 2) p , R 3 CON (R 4 ) (CH 2 ) p , R 3 R 4 NCO (CH 2 ) p or R 3 R 4 NSO 2 (CH 2 ) p (where R 3 and R 4 are each independently Or a hydrogen atom or a C 1-4 alkyl group, or R 3 R 4 forms part of a C 3-6 azacycloalkane or C 3-6 (2-oxo) azacycloalkane ring, and p is Zero or an integer of 1 to 4), or a group Ar 3 -Z, wherein Ar 3 is an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocycle. , selected from Z is a bond, O, S or CH 2) Is a substituent, R 2 is a hydrogen atom or a C 1-4 alkyl group, q is 1 or 2, s is an integer of zero 2, r is an integer of 1 4 , S + r are from 1 to 4, t is an integer from 0 to 1, u is an integer from 0 to 2, and A is the formula (a), (b) or (c): (In the formula, Ar is an aromatic heterocycle in either or optionally substituted bicyclic system, in which do or 5 or 6 membered be also substituted phenyl ring or substituted substituted, Ar 1 And Ar 2 are each independently a phenyl ring which may be substituted or a 5- or 6-membered aromatic heterocyclic ring which may be substituted, and Y is a bond, -NHCO-, -CONH-, -CH 2- or-(CH 2 ) m Y 1 (CH 2 ) n- where Y 1 is O, S, SO 2 or CO, and m and n are each zero or 1, but m + n Is 0 or 1, and when A is a group of formula (a), the substituent in Ar that is ortho to the carboxamide moiety must be hydrogen or a methoxy group) And a compound represented by the formula: A salt thereof. The compounds and salts thereof dopamine receptors of formula (I), details, has affinity to D 3 receptors and therefore, in the treatment of symptoms modulation of D 3 receptors is beneficial, for example, an anti-psychotic Has potential as a drug. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2019146739-A1 |
| priorityDate | 1997-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 102.