http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001524822-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10343 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-861 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 |
| filingDate | 1998-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001524822-A |
| titleOfInvention | Adenovirus vector containing a modified E4 region but carrying E4ORF3 |
| abstract | (57) [Summary]nThe present invention relates to transgene expression systems, related compositions containing the transgene expression systems, and methods of making and using them. A preferred system is an adenovirus transgene expression vector comprising a DNA encoding a transgene encoding a desired product operably linked to an expression control sequence, at least a portion of an E3 region, and some portions of an E4 region. Is used. The E4 portion includes a reading frame sequence known as E4ORF3 and at least one other portion of E4. Preferably, the E4 part of the vector ("E4 cassette") comprises E4ORF3 and at least one other part selected from E4ORF4, E4ORF6 / 7 and E4ORF3 / 4. The present invention has a number of important features, including improved persistence of transgene expression in a desired host cell. The transgene expression systems of the invention are useful for a variety of applications, including providing for sustained cellular expression of the transgene in vitro and in vivo. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007532656-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011224014-A |
| priorityDate | 1997-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 442.