| abstract |
(57) [Summary]nThe present invention provides materials and methods for efficiently and specifically reducing or removing unwanted mRNA. These materials and methods can be used in the treatment for retinal diseases. In one embodiment, a ribozyme that degrades mutant rod opsin mRNA is used to treat retinitis pigmentosa or diabetic retinopathy. In a further embodiment, ribozymes that cleave RNAs involved in nitric oxide activity are used to treat vascular retinal dysfunction. Preferred targets include VEGF, eNOS, and iNOS. |