http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001523441-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-142 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2539-103 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 |
| filingDate | 1998-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001523441-A |
| titleOfInvention | p53-induced apoptosis |
| abstract | (57) [Summary]nThe best documented biochemical property of p53 is its ability to transcriptionally activate genes. Many genes activated by p53 expression before the onset of apoptosis encode proteins capable of generating or responding to oxidative stress, including those associated with apoptosis in plant meristems It is predicted that. p53 can cause apoptosis through a three-step process: (i) transcriptional induction of certain redox-related genes: (ii) formation of reactive oxygen species (ROS); and (iii) rapid cell death Connected is the oxidative degradation of mitochondrial components. Transcription of other genes is reduced by p53. Testing of p53-induced or repressor gene transcript levels can be used to measure p53 status, to diagnose cancer, and to assess the cytotoxicity or carcinogenicity of test agents. is there. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101213033-B1 |
| priorityDate | 1997-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 302.