| abstract |
(57) [Summary]nAmyloid binding compounds that are derivatives of Chrysamine G, pharmaceutical compositions containing the compounds, and other compounds characterized by amyloidosis, such as to identify Alzheimer's disease brain in vivo, and Down's syndrome Methods of using the compounds to diagnose a pathological condition are disclosed. Pharmaceutical compositions containing Chrysamine G and its derivatives and methods of using the compounds to prevent cytopathic and amyloid-induced toxicity in conditions associated with amyloidosis are also described. Also described is the use of Chrysamine G derivatives to stain or detect amyloid deposition in biopsy or autopsy tissue. Also described is the use of a Chrysamine G derivative to quantify amyloid deposition in homogenates of biopsy and autopsy tissue. |