http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001522374-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1998-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001522374-A |
| titleOfInvention | Substituted tetrahydroisoquinolines as dopamine D3 receptor modulators |
| abstract | (57) [Summary] Formula (I): Wherein R 1 is a hydrogen or halogen atom; hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C 1-4 alkyl, C 1-4 alkoxy, aryl C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkoxy C 1-4 alkyl, C 3-6 cycloalkyl C 1-4 alkoxy, C 1-4 alkanoyl, C 1-4 alkoxycarbonyl, C 1- 4 alkylsulfonyl, C 1-4 alkylsulfonyloxy, C 1-4 alkylsulfonyl C 1-4 alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl C 1-4 alkyl, C 1-4 alkylsulfonamide, C 1- 4 alkylamide, C 1-4 alkyl sulfonamido C 1-4 alkyl, C 1-4 alkylamido C 1-4 alkyl, aryl sulfone A De, aryl carboxamido, aryl sulfonamido C 1-4 alkyl, aryl carboxamide C 1-4 alkyl, aroyl, aroyl C 1-4 alkyl or aryl C 1-4 alkanoyl group; group R 3 OCO (CH 2) p , R 3 CON (R 4 ) (CH 2 ) p , R 3 R 4 NCO (CH 2 ) p or R 3 R 4 NSO 2 (CH 2 ) p (where R 3 and R 4 are each independently Is a hydrogen atom or a C 1-4 alkyl group, or R 3 R 4 forms part of a C 3-6 azacycloalkane or C 3-6 (2-oxo) azacycloalkane ring, and p is zero. Or an integer of 1 to 4); or a group Ar 3 -Z wherein Ar 3 is an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring; location that is bound, O, selected from S or CH 2) A group; R 2 is hydrogen atom or a C 1-4 alkyl group; X is formula (a) or (b): Wherein Ar and Ar 1 are each independently a phenyl ring which may be substituted or a 5- or 6-membered aromatic heterocyclic ring which may be substituted; and Y is bond, -NHCO -, - CONH -, - CH 2 - or - (CH 2) m Y 1 (CH 2) n - a, where the Y 1 is O, S, SO 2 or CO, m and n is zero or one, respectively, such that the sum of m and n is zero or one; and Ar 2 is an optionally substituted phenyl ring or an optionally substituted five or six membered aromatic heterocycle. Or a bicyclic ring system which may be substituted.] And salts thereof. The compounds of formula (I) and their salts have affinity for dopamine receptors, in particular the D 3 receptor, and are therefore useful in the treatment of conditions in which modulation of the D 3 receptor is beneficial, for example, in the treatment of antipsychotics. Has potential as a drug. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002534519-A |
| priorityDate | 1997-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 144.