http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001522366-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 1998-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001522366-A |
| titleOfInvention | Substituted tetrahydroisoquinoline derivatives as modulators of dopamine D receptor 3 |
| abstract | (57) [Summary] Formula (I): Wherein R 1 is a hydrogen or halogen atom; hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy, trifluoromethanesulfonyloxy, pentafluoroethyl, C 1-4 alkyl, C 1-4 alkoxy, aryl C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 alkoxy C 1-4 alkyl, C 3-6 cycloalkyl C 1-4 alkoxy, C 1-4 alkanoyl, C 1-4 alkoxycarbonyl, C 1- 4 alkylsulfonyl, C 1-4 alkylsulfonyloxy, C 1-4 alkylsulfonyl C 1-4 alkyl, arylsulfonyl, arylsulfonyloxy, arylsulfonyl C 1-4 alkyl, C 1-4 alkylsulfonamide, C 1- 4 alkylamide, C 1-4 alkyl sulfonamido C 1-4 alkyl, C 1-4 alkylamido C 1-4 alkyl, aryl sulfone A De, arylcarboxamido, arylsulfonamido C 1-4 alkyl, aryl carboxamides C 1-4 alkyl, aroyl, aroyl C 1-4 alkyl or aryl C 1-4 alkanoyl group; group R 3 OCO (CH 2) p , R 3 CON (R 4 ) (CH 2 ) p , R 3 R 4 NCO (CH 2 ) p or R 3 R 4 NSO 2 (CH 2 ) p (wherein each of R 3 and R 4 is independently hydrogen Represents an atom or a C 1-4 alkyl group, or R 3 R 4 forms part of a C 3-6 azacycloalkane or C 3-6 (2-oxo) azacycloalkane ring, and p is 0 or Or a group Ar 1 Z (where Ar 1 represents an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring) , Z is shown coupled, O, S or CH 2) Indicates a substituent et selected; R 2 represents a hydrogen atom or a C 1-4 alkyl group; q is 1 or 2; Ar is be also substituted phenyl ring or substituted optionally be substituted A 5- or 6-membered aromatic heterocyclic ring; or an optionally substituted bicyclic ring system]. The compounds of formula (I) and their salts have affinity for dopamine receptors, in particular the D 3 receptor, and are therefore useful in the treatment of conditions in which modulation of the D 3 receptor is beneficial, for example as antipsychotics It has the possibility of. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2002534519-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007500730-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018021447-A1 |
| priorityDate | 1997-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.