| abstract |
(57) SUMMARY The present invention relates to the identification of novel genes and proteins ( Aop2 and AOP2, respectively), now referred to as antioxidant protein 2. Studies indicate that Ltw4 and Aop2 are single genes. Furthermore, AOP2 appears to be also a gene lead to At h1 traits in mice predisposition to atherosclerotic disease. Human homologs of this gene have also been identified. This discovery has led to the development of reagents that can be used for various uses of AOP2 and the corresponding genes, for example, in the diagnosis and treatment of atherosclerosis and related disease states (antibodies, expression vectors, cell lines, congenic and transgenic). Mouse) becomes possible. |