http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001520655-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1998-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001520655-A |
| titleOfInvention | 5,7-Disubstituted 4-aminopyrido [2,3-D] pyrimidine compounds and their use as adenosine kinase inhibitors |
| abstract | (57) [Summary] Formula (I) wherein R 1 and R 2 are independently H, lower alkyl, C 1 -C 6 alkoxy C 1 -C 6 alkyl, aryl C 1 -C 6 alkyl , -C (O) C 1 -C 6 alkyl, -C (O) aryl, or is selected from -C (O) heterocyclic group, or together with the nitrogen to which they are attached, O, N Or 5 to 7 members optionally containing 1-2 additional heteroatoms selected from S; R 3 is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl , arylalkyl, heteroaryl, heterocyclic group, selected from the group consisting of heteroaryl or heterocycloalkyl, the heteroaryl and heterocyclic groups are linked directly or indirectly to a ring carbon; R 4 Is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl , Aryl, arylalkyl, heteroaryl, heterocyclic groups selected from the group consisting of heteroarylalkyl or heterocycloalkyl; and dashed lines --- optionally a double bond as long as the appropriate valency is maintained Inhibiting adenosine kinase by administering a compound having a pharmaceutically acceptable carrier, a pharmaceutical composition comprising a therapeutically effective amount of said compound and a pharmaceutically acceptable carrier, cerebral ischemia, epilepsy, A method of treating nociception, inflammation and sepsis in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of the compound, manufacture of the compound. And a compound having the above formula, wherein R 1 , R 2 , R 3 and R 4 are independently defined. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015110666-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007500153-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011506502-A |
| priorityDate | 1997-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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