| abstract |
(57) [Summary]nChenyl-, furyl- and pyrrolyl-sulfonamides; pharmaceutically acceptable salts of sulfonamides; salts and formulations of the sulfonamides; and the use of the formulations and sulfonamides to modulate the activity of endothelin peptides Or a method of changing is provided. In particular, formulations of N- (isoxazolyl) thienylsulfonamides, N- (isoxazolyl) furylsulfonamides and sodium salts of N- (isoxazolyl) pyrrolylsulfonamides are provided. A method for producing an alkali metal salt of a hydrophobic sulfonamide is provided. The method includes the steps of dissolving free sulfonamide in an organic solvent in the presence of a saturated alkali metal salt solution and recovering the formed sulfonamide salt from the organic solvent. |