| abstract |
(57) The present invention provides a hydroxamic acid derivative of the formula (I) or a pharmaceutically acceptable salt or hydrate thereof, wherein X is (II) or (III), and Y is CR 1 R 2 , NR 3 or O, wherein R, R 1 , R 2 and R 3 are independently hydrogen, C 1 -C 9 straight or branched alkyl, C 2 -C 9 straight or branched alkenyl, C 3 -C 9 cycloalkyl, is selected from C 5 -C 7 group consisting of cycloalkenyl and Ar], to inhibit NAALADase activity pharmaceutical compositions, and in animals including such derivatives to treat glutamate abnormality, and It relates to the use of such derivatives for treating prostate disease. |