| abstract |
(57) [Summary]nThe present invention relates to substituted 3- (4-piperidinyl) indoles which are modulators, agonists or antagonists of the CCR5 receptor. In addition, the present invention includes, but is not limited to, asthma and atopic diseases (eg, atopic dermatitis and allergies), rheumatoid arthritis, sarcoidosis and other fibrotic diseases, atherosclerosis, psoriasis Treatment of conditions mediated by CCR5, including autoimmune diseases such as multiple sclerosis and inflammatory bowel disease, in all animals with the CCR5 receptor modulator 3- (4-piperidinyl) indole And prevention. Furthermore, since CD8 + T cells are involved in chronic obstructive pulmonary disease ("COPD"), CCR5 may play a role in their assembly and therefore antagonists to CCR5 are potent in treating COPD May provide a cure. In addition, receptor modulators may be useful in the treatment of HIV infection because CCR5 is a co-receptor for human immunodeficiency virus ("HIV") to enter cells. |