| abstract |
(57) [Summary]nA method for producing a novel PNA synthon suitable for a DNA synthesis reagent and equipment. The PNA synthon of the present invention is suitable for preparing various oligomers, particularly PNA-DNA chimeras. This PNA synthon is configured to be protected by an orthogonal protection method, and the protective group can be removed under mild conditions. Generally, a PNA synthon is created by linking a backbone with acid labile protection to a nucleobase side chain moiety. Further disclosed are methods for synthesizing backbones with acid labile protection and novel compositions of interest. |