| abstract |
(57) [Summary]nThe present invention relates to a compound of the formula (I)nEmbedded imagen Wherein X is N or CH; Y is NR Two CH Two , CH Two NR Two , NR Two CO, CONR Two Or NR Two SO Two Yes; where R Two Is H or C 1 ~ C 6 Alkyl; R 1 Is H, C 1 ~ C 6 Alkyl or C Three ~ C 6 R is cycloalkyl; Three Is C 1 ~ C 6 Alkyl, C Three ~ C 6 Cycloalkyl or (CH Two ) n Aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S, which are mono- or di-substituted N is 0-4; R 9 Is C 1 ~ C 6 Alkyl, C Three ~ C 6 Cycloalkyl, OCF Three , OCHF Two , OCH Two F, halogen, CONR 6 R 7 , CN, CF Three , OH, C 1 ~ C 6 Alkoxy, NR 6 R 7 , SO Three CH Three , SO Three CF Three , SO Two NR 6 R 7 , N and O, unsubstituted or substituted heterocyclic or heteroaromatic rings containing one or two heteroatoms wherein the substituent is C 1 ~ C 6 Alkyl) or COR 8 Where R 6 , R 7 And R 8 Has the above definition], and the novel piperidinyl- or piperazinyl-substituted 3,4-dihydro-2H-1- as (R) -enantiomer, (S) -enantiomer or racemate in free base form It relates to benzopyran derivatives or pharmaceutically acceptable salts or solvates thereof, processes for their preparation, pharmaceutical compositions containing their therapeutically active compounds and the use of these active compounds in therapy. |