http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001514662-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate | 1998-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001514662-A |
| titleOfInvention | Method of antagonizing human src SH2 domain |
| abstract | (57) SUMMARY The present invention is a method of treating a bone resorption disease in a subject, comprising administering to the subject a therapeutically effective amount of a compound that forms a covalent bond or linkage of the src SH2 domain to cys185. . Preferred compounds used herein are compounds of the present invention of the following formula (I): X = OR ", SR", NR "R"'; R "= H, methyl, alkyl; R"' = CONH 2, CONHMe, CONH alkyl, SONH 2, SONHMe, SONH alkyl, SO 2 NH 2, SO 2 NHMe, SO 2 NH-alkyl; n = 0,1,2; R = H , CH 2 CH (NHCOR "") CONHR ""', the organic moiety; R "" = glu-glu -ileu-glu-NH 2, Peptide, peptidomimetic, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl; R '= H, peptidomimetic; or fused ring system substituted with R, R' = H or peptidomimetic Or a hydrate of a pharmaceutically acceptable salt or solvate thereof. The present invention is also a pharmaceutical composition comprising a suitable pharmaceutical carrier and a compound of formula I. |
| priorityDate | 1997-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.