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filingDate 1998-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2001-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2001514511-A
titleOfInvention Screening using fluorescence anisotropy to identify compounds with affinity for nucleic acids
abstract (57) [Summary]nThe present invention provides methods for screening for biologically active compounds, particularly those that bind to RNA sequences involved in the regulation of disease pathogenesis or physiology. This method assesses the stability and / or conformation of an RNA target in the presence and absence of a test ligand, and produces any measurable change in stability and / or conformation of the target RNA. Identifying the test ligand as a ligand. In a preferred embodiment, the effect of the ligand on target RNA stability and / or conformation is assessed by measuring the fluorescence deflection of the fluorescently labeled probe.
priorityDate 1997-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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