| abstract |
(57) [Summary]nThe present invention provides for the delivery of immunomodulatory proteins or other biologically active proteins and / or antigenic epitopes in transient infections to prevent, ameliorate and / or eliminate infectious viral heart disease, Alternatively, it relates to the use of a cardiotropic viral vector with an attenuated Coxsackievirus to eliminate heart transplant rejection into infection. In addition, other organs or tissues can be targeted with particular picornaviruses. Specifically, an attenuated CVB3 viral vector capable of expressing a cytokine is provided. This cytokine expressing viral vector can deliver the cytokine to the target tissue and reduce the symptoms of the disease. |