| abstract |
(57) Summary The present invention relates to novel compounds of formula (I) and compositions thereof useful in the treatment of conditions mediated by chemokines, interleukin-8 (IL-8). In the compound of the formula (I), R is -NH-C (X) -NH- (CR 13 R 14 ) V -Z, and Z is an optionally substituted phenyl or naphthyl, and optionally substituted. heteroaryl, optionally substituted C 5-8 cycloalkyl, optionally substituted C 1-10 alkyl, optionally substituted C 2-10 alkenyl or optionally substituted C 2-10 A compound or a pharmaceutical thereof, wherein X is ニ ル O or ＝ S, A is a mono- or disubstituted carbon as described herein, and v is an integer from 1 to 4 Is an acceptable salt. Embedded image |