| abstract |
(57) [Summary]nThe present invention provides a method for inhibiting prenyl protein transferase and treating cancer, comprising administering to a mammal a prenyl protein transferase inhibitor that is an inhibitor of cellular processing of H-Ras and K4B-Ras proteins. provide. The invention particularly provides a method of inhibiting prenyl protein transferase and geranylgeranyl protein transferase type I by administering a compound that is a dual inhibitor of both of these prenyl protein transferases. The present invention provides for the convenient identification of compounds wherein the reading is a consequence of the biological activity of Ras-protein or of its activity, thereby inhibiting the cellular processing of H-Ras and K4B-Ras proteins. Methods for identifying such compounds are also provided. |