| abstract |
(57) [Summary]nb57 proteins and related nucleic acids are provided. Included are natural DAN and b57 homologs from several species and proteins containing DAN or b57 domains with specific activity, particularly the ability to antagonize bone morphogenetic proteins. Proteins can be produced recombinantly from host cells transformed with the nucleic acids of the invention. Also provided are isolated hybridization probes and primers capable of specifically hybridizing to the disclosed genes, specific binding agents, and methods of making and using the compositions of the present invention. |