http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001512116-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 |
| filingDate | 1998-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001512116-A |
| titleOfInvention | Oligo-thiophenes useful as antimetastatic agents, their preparation and pharmaceutical compositions containing them |
| abstract | (57) [Summary] Oligo-thiophenes of the following general formula (I): (In the formula, A -CH 2 -CO -, - be CH 2 CH 2 -CO- or -CH = CH-CO- group; or B is a 2-thienyl or phenyl group substituted by R groups , or N or terminal is a natural or synthetic amino acids linked to the a group via; or a-B is -CH 2 CH 2 -NH-A.A.- group, A.A. wherein - group is in the natural or synthetic amino acids linked to the CH 2 CH 2 -NH group via its carboxy terminus; R is hydrogen, or chlorine, bromine, iodine, fluorine, (C 1 -C 4) alkyl, (C 1 -C 4) alkylene -COOR in ', (C 1 -C 4) alkylene -NH 2, (C 1 -C 4) alkylene -NR' 2 or (C 1 -C 4) alkylene -NHCOR 'group There; R 'is hydrogen or (C 1 -C 4) alkyl group) isomers And it discloses the salts thereof with pharmaceutically acceptable acids and bases. Furthermore, the use of the compounds of formula (I) as inhibitors of uPA binding to specific uPAR receptors, especially as antitumor and anti-metastatic agents, is also claimed. |
| priorityDate | 1997-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 140.