http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2001510166-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N23-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 1998-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2001-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2001510166-A |
| titleOfInvention | Structure of ankyrin-binding domain of α-Na, K-ATPase |
| abstract | (57) [Summary]nThe association between ankyrin and the universal membrane proteins α-Na, K-ATPase, which are critical for the vector-wise transport of ions and nutrients, allows the assembly and stabilization of Na, K-ATPase in the membrane. is necessary. The present invention relates to the discovery that α-Na, K-ATPase is located in its second putative cytoplasmic domain, mainly through residues 142-166 (minimal ankyrin binding domain), in red blood cells (ANK1) and Madin Darby canine kidney. (MDCK) is directed to the disclosure of binding to both cellular ankyrin (ANK3). A glutathione-S-transferase fusion peptide incorporating these residues binds specifically to ankyrin. The three-dimensional structure of the minimal binding domain of the fusion peptide (2.6 °) reveals, for the first time, a seven-residue loop with two charged hydrophilic faces that caps the double β-strand. The invention includes peptides containing the minimal binding domain and analogs of these peptides. Another aspect of the invention includes a method for elucidating the minimal ankyrin binding domain (s) of other proteins that interact with ankyrin. Finally, the present invention relates to a method of screening for a compound that inhibits or enhances the binding of α-Na, K-ATPase or other ankyrin-binding protein to ankyrin, and ankyrin, and a protein that binds to the compound together with the compound. And a method for modulating the interaction between |
| priorityDate | 1997-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 96.