| abstract |
(57) [Summary]nThe present invention relates to parasitic nematode transglutaminase proteins, parasitic nematode transglutaminase nucleic acid molecules including those encoding such transglutaminase proteins, antibodies raised against such transglutaminase proteins, and parasitic nematode transglutaminase. A compound that inhibits activity. The invention further includes methods for obtaining such proteins, nucleic acid molecules, antibodies, and inhibitors. The present invention further provides therapeutic compositions containing such proteins, nucleic acid molecules, antibodies, and / or inhibitors, and such therapeutic compositions for protecting animals from diseases caused by parasitic nematodes. Use of the composition is included. The present invention further relates to the surprising discovery that the parasitic nematode transglutaminase protein has protein disulfide isomerase activity. Therefore, the present invention further relates to an inhibitor of the protein disulfide isomerase activity of the transglutaminase. |