| abstract |
SUMMARY A nitrosated and / or nitrosylated phosphodiesterase inhibitor having the formula, NO n -PDE inhibitor, wherein n is 1 or 2 is disclosed. Phosphodiesterase inhibitors can be nitrosylated or nitrosated at sites such as oxygen (hydroxyl condensation), sulfur (sulfhydryl condensation), carbon and nitrogen. The invention also provides for a composition comprising such a compound in a pharmaceutically acceptable carrier. The present invention also provides a therapeutically effective amount of a phosphodiesterase inhibitor (PDE inhibitor), optionally substituted with at least one NO or NO 2 group, and 1 to 10 times the molar concentration of a charged species or nitroso. A composition comprising a compound that donates, transfers or releases nitric oxide, either as ammonium (NO + ) or nitroxyl (NO − ) or as a neutral species, nitric oxide (NO.), Or stimulates endogenous EDRF production I will provide a. The invention also provides for a composition comprising such a compound in a pharmaceutically acceptable carrier. The present invention also provides a method of treating impotence in human males by administering the compounds and compositions thereof. |